Investigation of the Neuroprotective Action of Japanese Sake Yeast on Dementia Type of Alzheimer Disease in Rats: Behavioral and Neurobiochemical Assessment

Dementia involves several factors, and it is required to administer an agent with efficiencies for its treatment. Sake known have antioxidant anti-inflammatory properties improves the serum concentration of BDNF. This study aimed evaluate neuroprotective action Japanese sake yeast on dementia Alzheimer disease type in rats by behavioral evaluation neurobiochemical assessment. The were grouped as non-Alzheimer (control rats) administrated 0 (AD), 10 (10-AD), 20 (20-AD), 30 (30-AD), 40 mg/kg (40-AD) sake. Anxiety-like depression-like behaviors, concentrations brain-derived neurotrophic factor (BDNF), malondialdehyde (MDA), ferric reducing ability plasma (FRAP) evaluated. expressions IL-1β, TNF-α, IL-6 assessed. results showed that caused anxiety-like behaviors (p = 0.000), decreased BDNF 0.000) FRAP increased MDA IL-1β TNF-α 0.000). oral gavage higher doses reduced In sum, can roles treating type, but mechanisms must be assessed future studies.